氧空位诱导的TiO2/BiOI基光电化学分子印迹传感器的构建及多巴胺检测OA

Dopamine(DA),as an important neurotransmitter in the central nervous system,its precise detection is of great significance for the early diagnosis of diseases,treatment monitoring,and neurophysiological research.This study successfully constructed a TiO2/BiOI-based photoelectrochemical molecularly imprinted biosensor through an oxygen vacancies(OVs)regulation strategy.The introduction of OVs not only enhances the light absorption performance of TiO2/BiOI but also promotes the formation of P-N heterojunctions,facilitating the rapid separation of photo-generated carriers and significantly improving the sensor's sensitivity.Additionally,the introduction of OVs facilitates the modification of organic molecules on the electrode surface,thereby improving the sensor's selectivity and stability in dopamine detection.The results show that the sensor exhibits good linearity in dopamine detection over a range of 0.5～2.5 μmol/L,with a detection limit of 150.0 nmol/L.It also demonstrates strong non-specificity toward interfering biomolecules such as urea and glucose.This study provides a new approach for constructing high-sensitivity and high-selectivity molecularly imprinted photoelectrochemical biosensors by investigating the regulatory mechanism of oxygen vacancies,offering broad application prospects in biomolecular detection.