静态调强放疗与容积旋转调强放疗治疗鼻咽癌的对比研究OA

Objective To compare and analyze the clinical efficacy of static intensity modulated radiotherapy(s-IMRT)and volumetric modulated arc therapy(VMAT)in the treatment of nasopharyngeal carcinoma.Methods A retrospective analysis was performed on the clinical data of 78 patients with nasopharyngeal carcinoma admitted to our hospital from November 2024 to December 2025.Patients were divided into the s-IMRT group(35 cases,treated with s-IMRT)and the VMAT group(43 cases,treated with VMAT)according to different radiotherapy modalities,with consecutive radiotherapy for 6 weeks in both groups.The clinical remission rate,dosimetric parameters of target volume,levels of tumor markers and incidence of adverse reactions were compared between the two groups.Results No statistically significant difference was found in the overall clinical remission rate between the two groups(P＞0.05).The conformity index(CI)of the primary gross tumor volume(PGTV)in the VMAT group was significantly higher than that in the s-IMRT group(P＜0.05).No significant differences were found in the mean dose,maximum dose,minimum dose,and heterogeneity index(HI)of the PGTV between the two groups(P＞0.05).After treatment,the serum levels of carbohydrate antigen 125(CA125),cytokeratin 19 fragment(Cyfra21-1),and macrophage inflammatory protein-3α(MIP-3α)in the VMAT group were significantly lower than those in the s-IMRT group(P＜0.05).The incidences of oral mucositis,radiation dermatitis,leukopenia,and radiation-induced otitis media in the VMAT group were significantly lower than those in the s-IMRT group(P＜0.05).Conclusions Both s-IMRT and VMAT are effective therapeutic modalities for nasopharyngeal carcinoma.However,VMAT offers advantages in improving target conformity,reducing relevant tumor marker levels,and decreasing acute radiation-induced adverse reactions,making it a safer and more reliable option for clinical application.