低氧与高寒胁迫下高原动物肠道微生物的结构变化及生态适应性OA

The dynamics of gut microbial community in plateau animals are significantly affected by hypoxia and cold stress.Although mechanisms of plateau adaptation in animals have been extensively studied,the potential role of gut microbes in mediating plateau adaptation has been neglected.The interaction between gut microbiota and ecological factors in plateau animals was reviewed in this paper,and the effects of hypoxia and cold environment on the structure,gene,metabolic function and host of gut microbiota were analyzed,it was concluded that gut microbes help the host adapt to extreme environment by regulating energy metabolism,oxidative stress,digestion and absorption metabolism through intestinal-hepatic axis and bile acid metabolism.This paper provides new insights into adaptive evolution of plateau animals from the point of view of microbiome,and provides references for stress-resistant breeding in animal husbandry.