芪苈强心胶囊对兔心力衰竭模型电重构影响的研究OA

Objective To investigate the effect of Qiliqiangxin Capsule on electrical remodeling in a rab-bit heart failure model using microelectrode array(MEA)technology.Methods Sixty New Zealand rabbits were randomly divided into 6 groups(n=10):control group,heart failure group,Qiliqiangxin A group(10 mg/kg),Qiliqiangxin B group(20 mg/kg),Qiliqiangxin C group(40 mg/kg),and Qiliqiangxin D group(80 mg/kg).After successful heart failure modeling,the hearts were rapidly excised and subjected to langendorff perfusion.Flexible electrodes were attached to the ventricular myocardium to record changes in field action po-tential duration(fAPD),conduction velocity(CV),and heart rate(HR)in each group.Results Compared with the control group,the fAPD in the ventricular myocardium of the heart failure group was significantly pro-longed,CV was slowed,and HR was significantly accelerated,with statistically significant differences(P<0.05).Compared with the heart failure group,fAPD of ventricular myocardium was shortened,CV was accel-erated,and HR was slowed in all Qiliqiangxin groups,the differences were all statistically significant(P<0.05),with the effect showing a concentration-dependent enhancement.Conclusion Qiliqiangxin Capsule can significantly improve electrical remodeling in a rabbit heart failure model.