新型男性外生殖器自取样器在HPV检测中的应用研究OA

Objective:To assess the feasibility of a novel all-round self-sampling device for exfoliated cells from the male external genitalia in HPV detection,offering a new strategy for male HPV screening.Methods:Male spouses of HPV-positive women attending the Department of Cervical Diseases,Weifang People's Hospital from September 2024 to November 2025 were enrolled.Each participant received both traditional clinician-collected sampling and the novel self-sampling.HPV genotyping and viral load were detected by real-time fluorescent PCR.A questionnaire evaluated participants'HPV knowledge and acceptance of the new device.Re-sults:Among 398 participants,the overall HPV infection rate was 59.8％(238/398).The HPV detection rate with self-sampling was 50.5％(201/398),significantly higher than with clinician-collected sampling(40.7％,162/398;P<0.001).Self-sampling also yielded a signif-icantly higher median viral load(P<0.01).The survey showed 89.2％preferred self-sam-pling,with high ratings for convenience(99.4％),comfort(78.7％reported no discomfort),and privacy protection.Conclusion:The novel self-sampling device outperforms traditional cli-nician-collected methods in HPV detection rate,viral load sensitivity,and user experience,pro-ving to be a reliable,efficient,and readily promotable tool for male HPV testing.