基于熵权法联合灰色关联度法的贯众药材与饮片的质量评价OA

Objective To evaluate the quality of Rhizoma Dryopteridis herbal materials and decoction pieces using a combination of entropy weight(EW)and grey relation analysis(GRA).Methods 15 batches of Rhizoma Dryopteridis herbal materials and 9 batches of decoction pieces were selected.According to the general chapters of the Chinese Pharmacopoeia(中国药典)2020 Volume Ⅳ,10 indi-cators were measured for Rhizoma Dryopteridis herbal materials and decoction pieces,including moisture,total ash,acid-insoluble ash,extract,sulfur dioxide residue,heavy metals and harmful elements(including lead,cadmium,arsenic,mercury,and copper).The EW method was employed to determine the weights of each indicator,while GRA was applied to evaluate the quality of the herbal materials and decoction pieces.Results The content of the 10 indicators in the 15 batches of herbal materials and 9 batches of decoction pieces was almost consistent;the EW analysis showed that the moisture was generally lower than the other indicators among the low-quality indicators;copper had the highest information entropy and the lowest weight,at 0.9865 and 0.0469,respectively;moisture had the lowest information entropy and the highest weight,at 0.9349 and 0.2262,respectively;GRA showed that the correlation degrees of all evaluation indicators for the 15 batches of Rhizoma Dryopteridis herbal materials and 9 batches of decoction pieces relative to the opti-mal and worst reference sequences were relatively consistent,with moisture showing a close correlation.Additionally,combining EW with GRA,it was found that the relative correlation between the herbal medicine and the decoction pieces ranged from 0.3575 to 0.6431.The highest quality was the decoction piece batch Y5,and the lowest quality was the herbal medicine batch S2,indicating that there were significant quality differences among the 24 batches of samples collected;Finally,a comparison of the quality grades of the samples revealed that all were at Grade Ⅲ or above,with 19 batches at Grade I,3 batches at Grade Ⅱ,and 2 batches at Grade Ⅲ.All 9 batches of decoction pieces were classified as Grade I,while among the 15 batches of herbal materials,10 were Grade I,3 were Grade II,and 2 were Grade Ⅲ.Overall,the quality of the decoction pieces was superior to that of the herbal materials.Conclusion The EW and GRA models constructed based on multiple indicator components were used to evaluate the quality of different batches of Rhizoma Dryopteridis herbal materials and decoction pieces collected in this study.The method is simple and objective,providing a reference for quality control of Rhizoma Dryopteridis herbal materials and decoction pieces.