自体富血小板血浆灌注对中重度宫腔粘连术后子宫内膜再生修复的价值OA

Objective:To evaluate the clinical efficacy of autologous platelet-rich plasma(PRP)intrauterine perfusion in endometrial repair after transcervical resection of adhesions(TCRA)for moderate-to-severe intrauter-ine adhesions(IUA).Methods:From July 2023 to July 2024,seventy patients with moderate-to-severe IUA treated at Jiangxi Maternal and Child Health Hospital were randomly assigned to the PRP group(n=35)or the control group(n=35).Both groups underwent TCRA followed by hormonal therapy,while the PRP group received addi-tional intrauterine PRP perfusion immediately after surgery,and on postoperative days 7 and 14.Therapeutic effects were assessed viahysteroscopic scoring,menstrual improvement,endometrial thickness,clinical pregnancy outcomes and adverse reactions were recorded.Results:The PRP group exhibited significantly higher rates of u-terine cavity restoration(85.71%vs.60.00%,P=0.032),menstrual improvement(77.14%vs.48.57%,P=0.026)and thicker endometrium(7.97±1.19 mm vs.5.74±1.26 mm,P<0.001)compared to the control group.Al-though the clinical pregnancy rate did not reach statistical significance(57.14%vs.37.14%,P=0.082),the total live birth rate was significantly elevated in the PRP group(51.43%vs.28.57%,P=0.041).The incidence of ad-verse events was comparable between groups(28.57%vs.25.71%,P=0.788).Conclusions:Autologous PRP intrauterine perfusion effectively promotes the restoration of postoperative uterine anatomy and physiological func-tion in patients with moderate-to-severe IUA,significantly enhances menstrual improvement and live birth rates,and demonstrates a favorable safety profile.