老年细菌性肺炎病人28 d病死率与老年营养风险指数的相关性OA

Objective:To investigate the correlation between adverse outcomes and the Geriatric Nutritional Risk Index(GNRI)in elderly patients with bacterial pneumonia.Methods:Based on the MIMIC-Ⅳ 2.2 database,a total of 2 903 elderly patients with bacterial pneumonia were selected as the study subjects.Nutritional risk was classified into four grades according to GNRI.The relationship between 28-day mortality and GNRI in elderly patients with bacterial pneumonia was elucidated using restricted cubic splines(RCS),Kaplan-Meier regression analysis,Cox proportional hazards regression models,and subgroup analysis.The Boruta algorithm was employed to rank the importance of predictors for 28-day mortality.Results:A non-linear negative correlation was observed between 28-day mortality and GNRI in elderly patients with bacterial pneumonia(P<0.001).GNRI value of 90.281 was identified as the critical point for clinical intervention.An elevated GNRI was associated with reduced mortality.The results of the Cox proportional hazards regression model indicated that GNRI was a significant predictor of 28-day mortality(P<0.001).Subgroup analysis revealed that factors such as demographic characteristics and comorbidities did not have statistically significant impact on the relationship between 28-day mortality and GNRI(P>0.05).GNRI was identified as one of the key influencing factors for 28-day mortality.Conclusions:GNRI has demonstrated predictive value for short-term mortality in elderly patients with bacterial pneumonia.Nutritional support for elderly patients with bacterial pneumonia during treatment may reduce their mortality.