经典名方犀角地黄汤的历史沿革及处方考证OACHSSCD

Objective:To systematically investigate the historical evolution and key prescription information of Xijiao Dihuang De-coction using bibliometric methods,analyze its ancient and modern clinical applications,and provide guidance for clinical use.Methods:Ancient medical literature published before 1911 was retrieved from the 5th edition of Chinese Medical Canon,Duxiu Ac-ademic Search Database,Bolan Yishu,Traditional Chinese Medicine Think Tank,and other databases using"Xijiao Dihuang De-coction"as the keyword.Original ancient texts were consulted for verification and proofreading.Modern literature was retrieved from the China National Knowledge Infrastructure(CNKI),China Science Periodical Database(CSPD),and other databases using"Xi-jiao Dihuang Decoction"as the subject term.The search period ranged from January 1,1985 to April 30,2024,to obtain clinical re-search data on Xijiao Dihuang Decoction,followed by source verification and proofreading.The formula origin,historical evolution across dynasties,medicinal sources,dosage and processing methods,decoction and administration,as well as therapeutic effects and indications were systematically summarized and analyzed.Results:This formula originated from Shaoyao Dihuang Decoction in the Xiaopin Fang of the Northern and Southern Dynasties and was later collated by LIN Yi in the Northern Song Dynasty into the Impor-tant Prescriptions Worth a Thousand Gold for Emergency.Physicians of later generations generally inherited the original formula with further development.Based on textual research,the recommended medicinal materials and administration are as follows:con-centrated Bubali Cornu powder 138 g(as a substitute for rhinoceros horn),raw Rehmanniae Radix 110.4 g,raw Paeoniae Radix Rubra 41.4 g,and raw Moutan Cortex 27.6 g.The Chinese medicines are ground into coarse granules,decocted with 1 800 mL of water to a final volume of 600 mL per dose,and administered orally at 200 mL per dose,three times daily.The formula functions to cool the blood and resolve blood stasis,clear heat and expel pathogenic factors,nourish yin,and clear heat.It is mainly indicated for heat entering the blood aspect in typhoid fever and warm-disease conditions.Modern studies show that Xijiao Dihuang Decoction is commonly used in allergic purpura,psoriasis,thrombocytopenic purpura,systemic lupus erythematosus,and other diseases,whose pathogenesis is still classified as heat entering the blood aspect.Conclusion:A comprehensive bibliometric-based investigation of the historical evolution and key prescription information of Xijiao Dihuang Decoction provides a scientific basis for its standardized clinical application and pharmaceutical development.