通降颗粒中挥发油包合工艺研究OACHSSCD

Objective:To investigate the process conditions for β-cyclodextrin inclusion of volatile oil in Tongjiang Granules and to preliminarily characterize the inclusion complexes.Methods:The optimal inclusion process conditions for the volatile oil were de-termined using an orthogonal experimental design.The formation of new phases of the inclusion complexes was characterized using thin-layer chromatography(TLC),transmission electron microscopy(TEM),and ultraviolet-visible spectroscopy(UV-Vis).High-temperature stability was evaluated,and the optimal conformation between β-cyclodextrin and limonene was inferred using gas chro-matography(GC)and molecular docking.Results:The optimal inclusion conditions were determined to be a volatile oil(mL)to β-cyclodextrin(g)ratio of 1∶6,an inclusion temperature of 40 ℃,and a stirring time of 2 hours.After inclusion with β-cyclodextrin,the volatile oil formed a new phase.The thermal stability of the volatile oil was significantly improved.The β-cyclodextrin showed good affinity with limonene.Conclusion:This process enables the formation of stable inclusion complexes between volatile oil andβ-cyclodextrin,with a high inclusion efficiency and a simple procedure,demonstrating feasibility and rationality for practical pro-duction.