肺结核患者失眠严重程度与抗结核药物不良反应感知相关性OA

Objective:To explore the correlation between insomnia severity and the perception of adverse reactions to anti-tuber-culosis drugs in patients with pulmonary tuberculosis.Methods:A total of 62 pulmonary tuberculosis patients treated at Guang-zhou Chest Hospital from September 2023 to September 2025 were enrolled.The insomnia severity and perceived adverse reactions to anti-tuberculosis drugs were evaluated,and the correlation between these two variables was analyzed.Results:Age,disease du-ration and smoking history significantly affected patients' total Insomnia Severity Index(ISI)scores and total perceived adverse re-actions scores(P＜0.05).The total and dimension scores of perceived adverse reactions differed significantly among patients with different levels of insomnia severity(P＜0.05),with higher severity linked to higher scores(P＜0.05).The ISI score was posi-tively correlated with the total and dimension scores of perceived adverse reactions to anti-tuberculosis drugs(P＜0.05).Logistic regression identified that age,disease duration,and perceptions of gastrointestinal reactions,liver injury,and neurotoxicity were in-dependent predictors of insomnia severity in pulmonary tuberculosis patients(P＜0.05).Conclusion:Insomnia severity in pulmo-nary tuberculosis patients is positively correlated with their subjective perception of adverse reactions to anti-tuberculosis drugs.Moreover,the perception of adverse reactions serves as an independent predictor of insomnia severity.