基于"五神藏"理论探讨针刺治疗阿尔茨海默病的作用机制与临床研究进展OA

Alzheimer Disease(AD)is a prevalent chronic,progressive,and degenerative neurological disorder in the elderly.It presents as a clinical syndrome characterized by cognitive and memory decline,impaired daily living activities,psychiatric symptoms,and behavioral disturbances resulting from organic brain lesions.From the perspective of traditional Chinese medicine(TCM),the core pathogenesis involves the depletion of essence and qi within the five zang-organs.Based on the"five zang-organs storing spirits"theory,the close relationship between AD and the five spirits—specifically,xinshen(heart-mind),ganhun(liver-ethereal soul),piyi(spleen-intellect),feipo(lung-corporeal soul),and shenzhi(kidney-will)—demonstrates that AD is not merely a localized brain disorder.As a cornerstone of TCM,acupuncture harmonizes the five zang-organs and improves the circulation of qi and blood.Recent clinical and experimental studies have shown that acupuncture targeting specific acupoints based on the"five zang-organs storing spirits"theory effectively enhances cognitive function,memory,and behavioral performance.Its underlying mechanisms involve multi-target actions,including the regulation of beta-amyloid(Aβ)deposition and Tau protein phosphorylation,inhibition of neuroinflammation,and modulation of the gut microbiota.Acupuncture protocols derived from this theory embody the holistic TCM concept of the"unity of form and spirit",offering novel insights into AD prevention and treatment.While showing significant clinical potential,the underlying mechanisms require further in-depth investigation.