针刺联合低强度抗阻运动治疗老年肌少症的疗效观察OA
Clinical efficacy of acupuncture combined with low-intensity resistance exercise for sarcopenia in older adults
目的 观察针刺联合低强度抗阻运动治疗老年肌少症的临床疗效及安全性.方法 采用随机数字表法将130例老年肌少症患者分为对照组和观察组,每组65 例.两组均予相同的营养支持,对照组予低强度抗阻运动治疗,观察组予针刺联合低强度抗阻运动治疗.比较两组临床疗效及不良反应发生情况,观察两组治疗前后中医证候积分、躯体功能[简易机体功能评估(short physical performance battery,SPPB)评分和握力]和血清炎症因子[C反应蛋白(C-reactive protein,CRP)、白介素-6(interleukin-6,IL-6)和白介素-8(interleukin-8,IL-8)]水平的变化.结果 观察组总有效率为87.7%,高于对照组的 66.2%(P＜0.05).治疗后,两组中医证候积分各单项评分均较治疗前降低(P＜0.05),且观察组均低于对照组(P＜0.05).治疗后,两组SPPB 评分和握力均较治疗前提高(P＜0.05),且观察组高于对照组(P＜0.05).治疗后,两组血清CRP、IL-6和 IL-8 水平均较治疗前降低(P＜0.05),且观察组低于对照组(P＜0.05).两组不良反应总发生率比较,差异无统计学意义(P＞0.05).结论 在营养支持基础上,针刺联合低强度抗阻运动治疗老年肌少症可显著改善患者的临床症状,改善患者躯体功能,提高临床疗效,可能与减轻全身炎症反应有关.
Objective To observe the clinical efficacy and safety of acupuncture combined with low-intensity resistance exercise in the treatment of sarcopenia in older adults.Method A total of 130 older adults with sarcopenia were randomly assigned to a control group and an observation group using a random number table method,with 65 cases in each group.Both groups received the same nutritional support.The control group received low-intensity resistance exercise,whereas the observation group received acupuncture combined with low-intensity resistance exercise.Clinical efficacy and adverse events were compared between the two groups.Changes in traditional Chinese medicine(TCM)symptoms scores,physical function indicators[short physical performance battery(SPPB)score and handgrip strength],and serum inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),and interleukin-8(IL-8)]were assessed before and after treatment.Result The total effective rate was 87.7%in the observation group,significantly higher than 66.2%in the control group(P＜0.05).After treatment,scores for all individual TCM symptom items decreased significantly in both groups compared with baseline(P＜0.05),and were lower in the observation group than in the control group(P＜0.05).SPPB scores and handgrip strength increased significantly in both groups after treatment(P＜0.05),with greater improvements observed in the observation group(P＜0.05).Serum levels of CRP,IL-6,and IL-8 decreased significantly in both groups after treatment(P＜0.05),and were lower in the observation group than in the control group(P＜0.05).There was no significant difference in the overall incidence of adverse events between the two groups(P＞0.05).Conclusion On the basis of nutritional support,acupuncture combined with low-intensity resistance exercise can significantly improve clinical symptoms and physical function in older adults with sarcopenia,thereby enhancing clinical efficacy.These benefits may be associated with attenuation of systemic inflammatory responses.
何孝晴;李宁;徐素芝
河北省第八人民医院,石家庄 050022河北省第八人民医院,石家庄 050022河北省第八人民医院,石家庄 050022
医药卫生
针刺疗法抗阻运动肌少症炎症因子老年人
Acupuncture therapyResistance exerciseSarcopeniaInflammatory factorsElderly adults
《上海针灸杂志》 2026 (6)
636-641,6
河北省中医药管理局科研计划项目(2022413)
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