慢性阻塞性肺疾病合并肺癌的相关机制研究进展OA
Research Progress on Mechanisms of Chronic Obstructive Pulmonary Dis-ease Combined with Lung Cancer
慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)和肺癌是病死率最高的两大呼吸系统常见疾病,严重威胁人类生命健康.COPD 与肺癌具有显著的临床相关性,两种疾病具有共同的危险因素,两者潜在的分子机制具有一定的共同点,但 COPD 合并肺癌的发病机制非常复杂.为阐明两者之间的机制联系,本文从 COPD与肺癌之间的流行病学关联、共同发病机制角度出发对现有研究进行逐一梳理,深入综述了 COPD 到肺癌的核心转化机制,旨在为 COPD 合并肺癌的早期筛查、诊断和治疗方面提供新的、有益的研究方向.
Chronic obstructive pulmonary disease(COPD)and lung cancer are the two most common respiratory diseases and also those with the highest mortality rates,posing a serious threat to human life and health.There is a significant clinical correlation between COPD and lung cancer,and both diseases share common risk factors and potential molecular mecha-nisms.However,the pathogenesis of COPD combined with lung cancer is very complex.To clarify the relationship between these two diseases,this article reviews existing research from the perspective of epidemiological associations and co-pathogen-esis,and provides an in-depth overview of the core mechanisms underlying the transition from COPD to lung cancer,aiming to offer novel insights and directions for the early screening,diagnosis,and treatment of COPD combined with lung cancer.
李强;蔡亚丽;何艳;钟晓莉
641499 成都,简阳市人民医院 全科医学科641499 成都,简阳市人民医院 全科医学科641499 成都,简阳市人民医院 全科医学科641499 成都,简阳市人民医院 全科医学科
医药卫生
慢性阻塞性肺疾病肺癌慢阻肺合并肺癌发病机制炎症信号通路HIF-1α研究进展
Chronic obstructive pulmonary diseaseLung cancerCOPD combined with lung cancerPathogenesisIn-flammatory signaling pathwayHIF-1αResearch progress
《肿瘤预防与治疗》 2026 (6)
504-510,7
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