不同分子分型乳腺癌的钼靶与动态对比增强磁共振成像影像特征分析及检出率比较OA

Objective:To compare the differences in imaging features between mammography and dynamic contrast-en-hanced MRI(DCE-MRI)among different molecular subtypes of breast cancer,and to evaluate the detection rates of the two modalities when used alone or in combination for pathologically confirmed breast cancer.Methods:We retrospectively en-rolled 120 female patients with breast neoplasms confirmed by pathology who received mammography and DCE-MRI examina-tions from October 2019 to September 2024.Tumors were categorized according to immunohistochemical criteria into Luminal A,Luminal B(non-HER2-positive),HER2-positive(non-Luminal),and triple-negative breast cancer subtypes.The ima-ging features of mammography and DCE-MRI were compared across subtypes,and the detected case numbers and detection rates of the two modalities in each subtype were calculated.Results:Imaging features of mammography and DCE-MRI dif-fered across molecular subtypes.For Luminal A,Luminal B,and HER2-positive tumors,overall detection rates did not dif-fer among the three strategies(mammography,DCE-MRI,and the combination of the two)(P>0.05).For triple-negative tumors,overall detection rates differed significantly(P<0.05);pairwise comparisons using exact McNemar test with Bonferroni correction(α=0.017)showed that a statisti-cally significant difference existed only between mammography and the combined strategy(P<0.017).Conclusion:Mam-mography and DCE-MRI exhibit distinct imaging features across different molecular subtypes of breast cancer;combined ap-plication improves overall detection rates for pathologically confirmed breast cancer,with the greatest benefit observed in tri-ple-negative subtype.