多发性骨髓瘤患者生命质量测定量表之特异模块研制的条目筛选OA

Objective:Currently,there is a lack of appropriate quality-of-life assessment tools for patients with multiple myeloma(MM)in China.This study aimed to devel-op the disease-specific module of the Quality of Life Instru-ments for Patients with MM(QLICP-MM),based on the Quality of Life Instruments for Cancer Patients-General Module(Version 2.0)(QLICP-GM V2.0).Methods:Using QLICP-GM V2.0 as the basic framework,this study adopted a com-bined approach of a general module and a disease-specific module.An initial item pool was generated through topic-group dis-cussions,followed by several rounds of core-group reviews to develop the preliminary scale.A total of 30 patients with MM and 20 medical professionals participated in questionnaires and interviews.Item screening was performed using the variation meth-od,correlation coefficient method,Cronbach's α method,and clinician-patient importance rating method.Screening thresh-olds were set as follows:correlation coefficient>0.50,coefficient of variation>0.90,no increase in Cronbach's α after item deletion,patient importance score≥70 points,and medical staff importance score≥80 points.Results:A total of 16 candi-date items were included in the analysis.The coefficient of variation for each item ranged from 0.85 to 1.60;item-dimension correlation coefficients ranged from 0.24 to 0.78.Cronbach's α remained stable(0.84～0.87)after item deletion.Patient importance scores ranged from 65.33 to 90.33,and medical professional importance scores ranged from 77.50 to 92.50.Based on the statistical results,10 items were retained.After expert consultation,11 items were finalized for the test version of the QLICP-MM disease-specific module.Conclusion:Using a rigorous process combining qualitative and small-sample quantitative methods,this study developed the disease-specific module of QLICP-MM.The final 11 items show good content validity and in-ternal consistency,laying a foundation for the future development of the formal scale and its clinical validation.