PCL/SBPU静电纺小口径人工血管的制备及性能研究OA

To solve a series of problems such as platelet adhesion caused by the contact of small-diameter artificial blood vessels with blood,polycaprolactone(PCL)was selected as the main raw material.PCL small-diameter artificial blood vessels were prepared by electrospinning technology.Amphoteric ions polyurethane(SBPU)was loaded onto PCL artificial blood vessels for surface modification to regulate the blending ratio of PCL and SBPU.Four artificial blood vessels with different specifications were prepared,including PCL,PCL/SBPU5,PCL/SBPU10 and PCL/SBPU20.The antithrombotic performance was comprehensively analyzed through a series of performance tests and characterizations,such as its elemental structure,microscopic morphology and protein adsorption capacity.The results showed that the microstructure state of PCL/SBPU20 fibers was the best.The hydrophilicity of PCL/SBPU materials was increased as the increase of SBPU content.The tensile strength of PCL/SBPU20 was superior to that of PCL/SBPU5 and PCL/SBPU10.The adsorption capacities of BSA protein and Fg protein for the three groups of samples,namely PCL/SBPU5,PCL/SBPU10 and PCL/SBPU20,were all lower than those of the PCL sample.The L-LDH activity values of the three groups of samples,namely PCL/SBPU5,PCL/SBPU10 and PCL/SBPU20,were all lower than those of the PCL sample.The relative cell activities of the four groups of samples,namely PCL,PCL/SBPU5,PCL/SBPU10 and PCL/SBPU20,were all greater than 80%.It is believed that the surface modification of SBPU has certain anti-protein adsorption and anti-platelet adsorption effect,the performance of PCL/SBPU20 is the best.