颗粒物与噪声联合暴露对认知功能影响研究进展OA

With the accelerated global population aging and urbanization,cognitive dysfunction has become a major public health challenge.Epidemiological evidence indicates that long-term ex-posure to particulate matter and environmental noise are independent risk factors for cognitive decline,and recent studies suggest that their combined exposure may exert a synergistic ampli-fying effect.This review summarized the progress in epidemiological research on the impacts of particulate matter and noise exposure on cognitive function,specifically focusing on the synergistic effects of their combined exposure.Furthermore,it outlined common biological mechanisms such as neuroinflammation,oxidative stress,and vascular endothelial damage.However,while existing studies have preliminarily revealed the synergistic effects of combined particulate matter and noise exposure on cognitive function,the conclusions remain heterogeneous,and the inves-tigation of underlying mechanisms is still insufficient.Future research should prioritize refined exposure assessment,long-term cohort studies,and specific high-exposure occupational scenar-ios,and carry out further in-depth investigations,thereby providing a basis for health risk assess-ment and the development of intervention strategies.