大气颗粒物和二氧化氮急性暴露对健康成人血清生殖激素影响的定组研究OA
A panel study on effects of short-term exposure to ambient particulate matter and nitrogen dioxide on serum reproductive hormones in healthy adults
[背景]空气污染可对体内各系统和器官产生不利健康影响,但其对生殖健康的影响和相关生理学机制的研究仍有限. [目的]探究大气颗粒物和二氧化氮(NO2)急性暴露对健康成人血清中抗苗勒管激素和睾酮(T)水平的影响. [方法]招募 152名健康成年志愿者,采用定组研究设计,在 2019年 1月—2020年 1月期间进行 4次随访,收集基本信息,采集血清,使用酶联免疫吸附试剂盒测定生殖激素水平;监测研究区域同期细颗粒物(PM2.5)、黑碳(BC)、NO2 浓度,以及粒径段 5～560 nm的颗粒物数浓度(PNC5_560)和气象资料.利用线性混合效应模型分析大气颗粒物和 NO2 急性暴露对血清生殖激素的影响. [结果]研究对象平均年龄为(23.9±2.4)岁,女性 102人.PM2.5、PNC5_25、PNC100_560、BC和 NO2的滑动平均浓度每升高1个四分位间距,女性血清抗苗勒管激素水平分别降低10.2%～16.9%、46.2%～58.0%、16.9%～21.2%、14.8%～26.5%和11.3%～17.6%,在腰臀比(WHR)>0.76和体力活动水平≤1 217代谢当量(MET)·min·周-1 的研究对象中,该降低效应更强;男性血清游离睾酮水平降低分别为 11.1%～17.2%、35.2%、10.5%～18.9%、18.7%～24.2%和 10.3%～26.0%,在 WHR>0.81和体力活动水平≤1 498 MET·min·周-1 的研究对象中,该降低效应更强. [结论]颗粒物和 NO2 急性暴露与健康成人血清中抗苗勒管激素和 T水平降低显著相关,且该负面效应在人群腰臀比较高时更强.
[Background]Air pollution has widespread adverse health effects on human health,but research on its impact on reproductive health and related physiological mechanisms remains insufficient. [Objective]To investigate the associations between short-term exposure to particulate matter and nitrogen dioxide(NO2)and serum levels of anti-Müllerian hormone(AMH)and testosterone in healthy adults. [Methods]A total of 152 healthy adults were recruited for a panel study,undergoing four follow-up visits from September 2019 to January 2020.Basic demographic information and serum sam-ples were collected.Reproductive hormone levels were measured by enzyme-linked immunosor-bent assay kits.Concurrently,environmental data in the study area were monitored,including fine particulate matter(PM2.5),black carbon(BC),NO2,particle number concentrations in the 5-560 nm size fraction(PNC5_560),and meteorological variables.Linear mixed-effects models were constructed to estimate the effects of short-term exposure to these particulate matter on serum reproductive hormone levels. [Results]The participants had an average age of(23.9±2.4)years,with 102 women.For each interquartile range(IQR)increment in pollutant moving average concentrations,PM2.5,PNC5_25,PNC100_560,BC,and NO2 were associated with relative decreases in female serum AMH levels by 10.2%-16.9%,46.2%-58.0%,16.9%-21.2%,14.8%-26.5%,and 11.3%-17.6%,respectively.These negative associations were stronger in females with waist-to-hip ratio>0.76 and physical activity levels≤1 217 metabolic equivalents(MET)min per week.Similarly,in males,an IQR increase in the same pollutants was associated with relative decreases in serum free testosterone by 11.1%-17.2%,35.2%,10.5%-18.9%,18.7%-24.2%,and 10.3%-26.0%,respectively.These effects were more pronounce in male with a waist-to-hip ratios>0.81 and physical activity levels≤1 498 MET-min per week. [Conclusion]Short-term exposure to particulate matter and NO2 may reduce serum levels of AMH and testosterone in healthy adults.Furthermore,these adverse effects appears to be stronger in adults with higher waist-to-hip ratios.
方言;何兴侯;赵二璐;张彬;朱雨桐;王童;宋晓明;徐洪兵;黄薇
北京大学公共卫生学院,北京 100191北京大学公共卫生学院,北京 100191北京大学公共卫生学院,北京 100191北京大学公共卫生学院,北京 100191北京大学公共卫生学院,北京 100191北京大学公共卫生学院,北京 100191北京大学公共卫生学院,北京 100191中国医学科学院放射医学研究所,天津 300192北京大学公共卫生学院,北京 100191
医药卫生
颗粒物二氧化氮抗苗勒管激素睾酮定组研究
particulate matternitrogen dioxideanti-Müllerian hormonetestosteronepanel study
《环境与职业医学》 2026 (6)
709-716,729,9
国家自然科学基金项目(81773381)北京市自然科学基金项目(7222246) This study was funded.
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