瘤内微生物代谢对肿瘤的双重效应OA

Research has confirmed that tumor tissues are not in a sterile state,but rather host microbial communities with tumor-specific characteristics.These intratumoral microorganisms not only directly promote or inhibit tumorigenesis themselves,but can also influence tumor development and therapeutic responses through their active metabolic activities.This review examines the effects and mechanisms of intratumoral microbial metabolism on tumors from both pro-tumoral and anti-tumoral perspectives,and summarizes novel strategies for tumor prevention and treatment based on intratumoral microbial metabolism.The precise regulatory network of intratumoral microbial metabolism on tumors requires further investigation.Elucidating its dual effects and molecular mechanisms on tumors is expected to provide new directions for tumor prevention and treatment.