家庭护士食疗理论在超重/肥胖冠心病病人中的实证研究OA

Objective:To construct an optimized dietary therapy program based on the Family Nurse Diet Therapy theory and verify its intervention effect in overweight/obese patients with coronary artery disease.Methods:A single-arm trial design was adopted,and 66 overweight/obese patients with coronary heart disease were included for a 6-week dietary therapy optimization program intervention(family nurse® protein compound powder replacing staple food+family nurse®5·20 substitute tea).Changes in anthropometric,inflammation,oxidative stress,glycipid metabolism,quality of life and other indicators before and after the intervention were compared.At the same time,propensity score matching(1∶1)was adopted to compare with the previous 32 historical controls(basic dietary therapy plans)of our research group.Results:After 6 weeks of intervention,the patients'weight,body mass index(BMI),body fat mass,visceral fat area,and blood pressure all decreased significantly(P＜0.05);Hypersensitive C-reactive protein and malondialdehyde were significantly decreased,while superoxide dismutase was increased(P＜0.001).Triglycerides,low-density lipoprotein,fasting blood glucose,fasting insulin,insulin resistance index,homocysteine and uric acid decreased significantly,while high-density lipoprotein increased(P＜0.05).The quality of life score increased,while the anxiety and depression scores decreased(P＜0.001).The compliance was good(95.5％),and 7 patients achieved drug reduction.Compared with the historical control,the optimized plan had a better effect in reducing body weight,BMI,blood glucose and uric acid(P＜0.05).Conclusion:The optimized dietary therapy regimen based on the Family Nurse Diet Therapy can improve metabolic disorders,inflammation,and oxidative stress in overweight/obese patients with coronary heart disease in multiple dimensions,improve QOL,and has good safety and compliance,further validating the scientific validity and effectiveness of the iterative upgrade of the regimen.