外周血GPR、ANGPTL2水平及血脂代谢与原发性高血压合并不稳定型心绞痛患者冠状动脉病变的相关性OA
Correlation of peripheral blood GPR,ANGPTL2 level,and lipid metabolism with coronary artery lesions in patients with essential hypertension complicated by unstable angina pectoris
目的 探讨外周血γ-谷氨酰基转移酶与血小板比值(γ-glutamyl transferase to platelet ratio,GPR)、血管生成素样蛋白2(angiopoietin-like protein 2,ANGPTL2)水平及血脂代谢与原发性高血压(essential hypertension,EH)合并不稳定型心绞痛(unstable angina pectoris,UAP)患者冠状动脉病变的相关性.方法 选取EH合并UAP患者80例(EH合并UAP组),同时选取单纯EH患者80例(EH组)、单纯UAP患者80例(UAP组)以及健康体检者80例(健康组)作为对照,比较各组外周血GPR、ANGPTL2水平及血脂代谢指标[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]的差异,同时分析EH合并UAP组不同冠状动脉病变程度患者上述指标间的差异.结果 EH合并UAP组患者外周血GPR和ANGPTL2水平明显高于UAP组、EH组和健康组(均P＜0.05);EH合并UAP组患者LDL-C水平明显高于UAP组、EH组和健康组(均P＜0.05).亚组分析结果显示,EH合并UAP组中冠状动脉重度病变患者外周血GPR和ANGPTL2水平明显高于轻度和中度病变患者(均P＜0.05);TC、TG和LDL-C明显高于轻度和中度病变患者(均P＜0.05),而HDL-C明显低于轻度和中度病变患者(P＜0.05).Spearman相关性分析显示,外周血GPR、ANGPTL2、LDL-C水平与冠状动脉病变程度呈正相关(rs分别为0.514、0.577和0.489,均P＜0.001).结论 外周血GPR、ANGPTL2及LDL-C水平变化可在一定程度上反映EH合并UAP患者冠状动脉病变负荷,联合监测上述指标有助于评估冠状动脉病变程度,并为临床风险分层提供参考.
Objective To investigate the correlation of peripheral blood γ-glutamyl transferase to platelet ratio(GPR),angiopoietin-like protein 2(ANGPTL2)level,and lipid metabolism with coronary artery lesions in patients with essential hypertension(EH)complicated by unstable angina pectoris(UAP).Methods A total of 80 patients with EH complicated by UAP(EH+UAP group)were enrolled.Additionally,80 patients with EH alone(EH group),80 patients with UAP alone(UAP group),and 80 healthy controls(healthy group)were included for comparison.The levels of peripheral blood GPR and ANGPTL2,and lipid metabolism parameters[total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)]were compared among groups.Subgroup analyses were performed within the EH+UAP group based on the severity of coronary artery lesions.Results Peripheral blood GPR and ANGPTL2 level in the EH+UAP group were significantly higher than those in the UAP group,EH group,and healthy group(all P＜0.05).LDL-C level in the EH+UAP group was also significantly higher than that in the other three groups(all P＜0.05).Subgroup analysis showed that in patients with severe lesions(within the EH+UAP group),peripheral blood GPR and ANGPTL2 level were significantly higher than those in patients with mild or moderate lesions(all P＜0.05).Levels of TC,TG,and LDL-C were significantly higher,while HDL-C was significantly lower in patients with severe lesions compared with mild or moderate lesions(all P＜0.05).Spearman correlation analysis revealed that peripheral blood GPR,ANGPTL2,and LDL-C levels were positively correlated with the severity of coronary artery lesions(rs=0.514,0.577 and 0.489,respectively;all P＜0.001).Conclusion Changes in peripheral blood GPR,ANGPTL2,and LDL-C level can reflect,to some extent,the coronary artery lesion burden in patients with EH complicated by UAP.Combined monitoring of these indicators may assist in evaluating the severity of coronary artery lesions and providing reference for clinical risk stratification.
毛亚萍;王金成
212300 江苏镇江,丹阳市第三人民医院检验科212300 江苏镇江,丹阳市第三人民医院检验科
医药卫生
γ-谷氨酰基转移酶与血小板比值血管生成素样蛋白2血脂原发性高血压不稳定型心绞痛
γ-glutamyl transferase to platelet ratioangiopoietin-like protein 2blood lipidessential hypertensionunstable angina pectoris
《实用心电与临床诊疗》 2026 (3)
444-448,454,6
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