肠道菌群与心房颤动风险的因果关联:基于两样本孟德尔随机化研究OA

Objective To investigate the causal associations between specific gut microbiota and the risk of atrial fibrillation(AF),and to evaluate the potential reverse effects of AF on gut microbiota.Methods A two-sample Mendelian randomization(MR)approach was employed to analyze bidirectional relationships between 19 gut microbial taxa and AF,based on the Genome-Wide Association Study(GWAS)summary statistics from the FinnGen consortium.Forward analysis included Bacillus group C,Bifidobacterium,unnamed strain sp003534295 of CAG-273,Cyanobacteria,Fimbriimonadia,Firmicutes group A,and Jiangellaceae.Reverse analysis included unnamed strain sp000435175 of CAG-245,CAG-245 group,Coprobacillus cateniformis,Coprobacillus,Megasphaera,Phocea sp.,Propionibacterium freudenreichii,Succinivibrio,Thermococcaceae,Thermococci,and unnamed strain sp900313925 of UBA2922.Robustness was assessed using inverse variance weighted,MR-Egger regression,and weighted median methods,with multiple comparisons corrected using a false discovery rate(FDR)threshold of＜0.05.Results Higher abundances of Bifidobacterium,unnamed strain sp003534295 of CAG-273,Cyanobacteria,Fimbriimonadia,and Jiangellaceae were associated with a reduced risk of AF;Bacillus group C and Firmicutes group A showed positive associations with AF.AF led to increased abundances of Coprobacillus,Coprobacillus cateniformis,Phocea sp.,Propionibacterium freudenreichii,and Thermococcaceae,while the abundances of unnamed strain sp000435175 of CAG-245,CAG-245 group,Megasphaera,and Succinivibrio decreased.Conclusion Multiple gut microbial taxa exhibit genetically predicted causal relationships with AF in different directions,and AF itself can reshape the gut microbiome.The"gut-heart axis"may be involved in the pathogenesis and progression of AF,offering potential targets for microbiota-based interventions.