持续性非卧床腹膜透析患者的透析充分性及其影响因素分析OA

To investigate the dialysis adequacy in patients on continuous ambulatory peritoneal dialysis(CAPD)and analyze its influencing factors,so as to provide an evidence-based reference for clinical practice.Methods A total of 162 patients who underwent regular CAPD at the Second Affiliated Hospital of Wenzhou Medical University from June 2022 to March 2024 were selected as the observation group,and 40 healthy individuals undergoing physical examinations during the same period were enrolled as the control group.Data on general information,CAPD knowledge,self-care ability,and laboratory indicators were collected,and CAPD-related symptoms were evaluated.Logistic regression was used to analyze the factors influencing dialysis adequacy.Results Among the 162 patients,86(53.09%)achieved adequate dialysis.Significant differences were observed between the adequate and inadequate dialysis groups in terms of CAPD duration,CAPD knowledge and self-care ability scores,C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),D/D0,albumin,total protein,interleukin-10(IL-10),residual renal function(RRF),peritoneal creatinine clearance(CCr),peritoneal Kt/V,and scores for skin symptoms,gastrointestinal symptoms,and water-electrolyte disturbances(all P<0.05).Logistic regression analysis showed that longer CAPD duration,higher CRP,IL-6,TNF-α,D/D0,and gastrointestinal symptoms were risk factors for inadequate dialysis,while better CAPD knowledge,higher self-care ability,higher albumin level,better RRF,higher peritoneal CCr,and higher peritoneal Kt/V were protective factors(all P<0.05).Conclusions The proportion of CAPD patients with inadequate dialysis is relatively high.It may help reduce the risk of inadequate dialysis in CAPD patients by improving CAPD knowledge and self-care ability of patients,as well as increasing levels of albumin,RRF,peritoneal CCr,and peritoneal Kt/V.