甲钴胺联合依帕司他治疗糖尿病周围神经病变的效果OA

Objective To study the clinical effect of Mecobalamin combined with Epalrestat in the treatment of patients with diabetes peripheral neuropathy.Methods A total of 100 patients with diabetic peripheral neuropathy admitted to Shangrao Central Hospital from April 2024 to April 2025 were selected as the study subjects.They were divided into the experimental group(50 cases)and the control group(50 cases)according to random number table method.The control group received conventional Mecobalamin treatment,while the experimental group received Mecobalamin combined with Epalrestat treatment.The efficacy,nerve conduction velocity(NCV),and adverse reactions of the two groups were compared and analyzed.Results The effective rate of the experimental group after treatment was higher than that of the control group,and the difference was statistically significant(P＜0.05).After treatment,the NCV of the tibial nerve,common peroneal nerve,and plantar nerve in the experimental group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The total incidence of adverse reactions in the experimental group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion Mecobalamin is effective in the treatment of patients with diabetes peripheral neuropathy.The combined use of Epalrestat in this process can further enhance the efficacy,promote the increase of patients'nerve conduction velocity,and ensure the recovery effect of patients,which is worthy of clinical promotion.