黄连素对直肠异常隐窝病灶氩气喷凝术后复发的影响OA

Objective To investigate the effect of Berberine on recurrence of rectal aberrant crypt foci(ACF)after argon plasma coagulation(APC),in order to provide a basis for clinical optimization of postoperative treatment strategy for rectal ACF.Methods From May 2023 to March 2024,a total of 60 patients with rectal ACF admitted to Guangzhou Hospital of Integrated Traditional Chinese and Western Medicine were selected as the research objects.According to the random number table method,they were divided into Berberine group(30 cases)and placebo group(30 cases).Both groups received APC treatment to remove ACF in the rectum,and oral medication was started 1 week after surgery.The Berberine group was treated with Berberine Tablets,and the placebo group was treated with the same dose of placebo.The recurrence-related indicators,adverse reactions and changes in liver and kidney function were compared between the two groups.Results The recurrence rate of the Berberine group was 26.67%,which was lower than 56.67%of the placebo group,and the difference was statistically significant(P＜0.05).There were no significant differences in the recurrence rates between the two groups at 6 and 18 months after operation(P＞0.05).The severity of adverse reactions in the two groups was mainly mild,and there was no statistically significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).The incidence of abdominal pain in the Berberine group was 26.67%,which was higher than 3.33%in the placebo group,and the difference was statistically significant(P＜0.05).After treatment,there were no statistically significant differences in alanine transaminase,aspartate transaminase,total bilirubin,creatinine and urea nitrogen levels between the two groups(P＞0.05).Conclusion Berberine treatment in patients with rectal ACF can reduce the recurrence rate of 12 months after surgery,and it is safe in clinical application and well tolerated by patients,which can provide a basis for clinical formulation of drug intervention strategies for postoperative recurrence of rectal ACF.