鼻负压置换联合雾化治疗儿童肺炎的效果分析及对痰培养转阴影响OA
Analysis of the effect of nasal negative pressure replacement combined with inhalation therapy in the treatment of pediatric pneumonia and its influence on the negative conversion of sputum culture
目的 分析鼻负压置换联合雾化治疗儿童肺炎的效果,并探讨其对痰培养转阴的影响.方法 选取2024年3月至12月莆田学院附属医院收治的136例儿童肺炎患者作为研究对象,按照随机数字表法分为参照组(68例)与试验组(68例).所有患儿均行抗感染、化痰治疗,参照组同时予以雾化治疗,试验组在参照组方法的基础上增加鼻负压置换治疗.比较两组的临床疗效、痰培养转阴情况、临床症状情况、炎症指标、急性生理学与慢性健康状况评估Ⅱ(APACHEⅡ)评分、临床肺部感染评分.结果 试验组的治疗总有效率、痰培养转阴率均高于参照组,差异有统计学意义(P＜0.05);试验组的发热、咳嗽、流涕症状转归时间和住院天数均短于参照组,差异有统计学意义(P＜0.05);试验组治疗后的白细胞计数(WBC)、C反应蛋白(CRP)水平均低于参照组,差异有统计学意义(P＜0.05).试验组治疗后的APACHE Ⅱ评分、临床肺部感染评分均低于参照组,差异有统计学意义(P＜0.05).结论 在儿童肺炎的抗感染治疗基础上,采取鼻负压置换联合雾化治疗的方式,能取得更好的效果,可以有效地提升痰培养的转阴率,对尽快缓解症状和降低炎症指标发挥出更好的效果,值得应用.
Objective To analyze the effect of nasal negative pressure replacement combined with inhalation therapy in the treatment of pediatric pneumonia,and to explore its influence on the negative conversion of sputum culture.Methods A total of 136 patients with pediatric pneumonia admitted to the Affiliated Hospital of Putian University from March to December 2024 were selected as the research objects.According to the random number table method,they were divided into the reference group(68 cases)and the experimental group(68 cases).All children were treated with anti-infection and expectoration.The reference group was treated with inhalation therapy at the same time,and the experimental group was treated with negative pressure replacement on the basis of the reference group.The clinical efficacy,sputum culture negative conversion,clinical symptoms,inflammatory indicators,acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ)score,and clinical pulmonary infection score were compared between the two groups.Results The total effective rate of treatment and negative conversion rate of sputum culture in the experimental group were higher than those in the reference group,and the differences were statistically significant(P＜0.05).The recovery time of fever,cough and runny nose symp-toms and the length of hospital stay in the experimental group were shorter than those in the reference group,and the differences were statistically significant(P＜0.05).After treatment,the white blood cell count(WBC)and C-reactive protein(CRP)levels of the experimental group were lower than those of the reference group,and the differences were statistically significant(P＜0.05).After treatment,the APACHE Ⅱ score and clinical pulmonary infection score of the experimental group were lower than those of the reference group,and the differences were statistically significant(P＜0.05).Conclusion On the basis of anti-infection treatment for pediatric pneumonia,nasal negative pressure replacement combined with inhalation therapy can achieve better results,effectively improve the negative conversion rate of sputum culture,relieve symptoms and reduce inflammatory indicators as soon as possible,which is worthy of application.
林东;郑立娴
莆田学院附属医院儿科,福建莆田 351100莆田学院附属医院产科,福建莆田 351100
医药卫生
鼻负压置换雾化治疗儿童肺炎痰培养转阴
Nasal negative pressure replacementInha-lation therapyPediatric pneumoniaNegative conversion of sputum culture
《中国当代医药》 2026 (14)
39-43,5
福建省莆田市科技计划项目(2024SJYL082).
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