宫腔镜手术+地屈孕酮治疗子宫内膜息肉的效果及对子宫内膜厚度的影响OA
Effect of hysteroscopic surgery+Dydrogesterone in the treatment of en-dometrial polyps and its influence on endometrial thickness
目的 探讨宫腔镜手术后尽早联合使用地屈孕酮治疗子宫内膜息肉的效果,分析其对患者术后子宫内膜厚度及复发率的影响,为临床治疗方案的选择提供参考.方法 选取2022年10月至2025年4月山东滨州医学院附属医院妇科就诊的146例子宫内膜息肉患者作为研究对象,按照随机数字表法将其分为对照组(73例)和观察组(73例).对照组采用宫腔镜手术治疗,观察组采用宫腔镜联合地屈孕酮治疗.比较两组的治疗效果、子宫内膜厚度、激素水平,以及不良反应发生情况.结果 观察组的总有效率高于对照组,复发率低于对照组,差异有统计意义(P＜0.05).治疗前,两组患者的子宫内膜厚度和激素水平比较,差异无统计意义(P＞0.05).术后3、6个月,观察组的子宫内膜厚度低于对照组,差异有统计意义(P＜0.05);术后6个月,观察组的促黄体生成素、雌二醇水平均低于对照组,孕酮水平高于对照组,差异有统计意义(P＜0.05).两组患者的不良反应总发生率比较,差异无统计学意义(P＞0.05).结论 子宫内膜息肉患者实施宫腔镜手术治疗后,联合运用地屈孕酮取得的疗效突出,能有效调控患者体内的激素水平,优化子宫内膜厚度,从而减少复发风险,且安全性良好,值得临床采纳.
Objective To investigate the effect of Dydrogesterone in the treatment of endometrial polyps as soon as possible after hysteroscopic surgery,analyze its effect on postoperative endometrial thickness and recurrence rate,and provide reference for the selection of clinical treatment.Methods A total of 146 patients with endometrial polyps in Binzhou Medical University Hospital from October 2022 to April 2025 were selected as the research objects.According to the random number table method,they were divided into the control group(73 cases)and the observation group(73 cases).The control group was treated with hysteroscopic surgery,and the observation group was treated with hysteroscopic surgery combined with Dydro-gesterone.The treatment effect,endometrial thickness,hormone levels,and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the recur-rence rate was lower than that of the control group,and the differences were statistically significant(P＜0.05).Before treat-ment,there were no statistically significant differences in endometrial thickness and hormone levels between the two groups(P＞0.05).At 3 and 6 months after surgery,the endometrial thickness of the observation group were lower than those of the control group,and the differences were statistically significant(P＜0.05).Six months after surgery,the levels of luteinizing hormone and estradiol in the observation group were lower than those in the control group,and the level of progesterone was higher than that in the control group,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion After hys-teroscopic surgery for patients with endometrial polyps,the combined use of Dydrogesterone has outstanding curative effect,which can effectively regulate the hormone levels of patients,optimize the endometrial thickness,so as to reduce the risk of recurrence,and has good safety,which is worthy of clinical adoption.
贾相奇;张晓童;孙苗苗;姚宗花
滨州医学院附属医院妇科,山东滨州 256600滨州医学院附属医院妇科,山东滨州 256600滨州医学院附属医院妇科,山东滨州 256600滨州医学院附属医院妇科,山东滨州 256600
医药卫生
宫腔镜手术地屈孕酮子宫内膜息肉疗效子宫内膜厚度
Hysteroscopic surgeryDydrogesteroneEn-dometrial polypsTherapeutic effectEndometrial thickness
《中国当代医药》 2026 (14)
35-38,4
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