血清颗粒蛋白前体、正五聚蛋白3 水平对牙列缺失患者口腔种植修复术后种植体周围黏膜炎的预测价值OA

Objective To explore the predictive value of serum progranulin(PGRN)and pentraxin 3(PTX3)levels for peri-implant mucositis in patients with edentulism after oral implant restoration.Methods A total of 153 patients who underwent oral implant restoration at Heze Medical College Affiliated Hospital from December 2021 to December 2024 were selected as the research subjects.According to the occurrence of peri-implant mucositis in patients with tooth loss 6 months after im-plant restoration,they were divided into the mucositis group(41 cases)and the non-mucositis group(112 cases).The levels of serum PGRN and PTX3 were detected by ELISA method.Multivariate logistic analysis was used to analyze the influencing factors of peri-implant mucositis in patients with tooth loss after surgery.The relative risk of peri-implant mucositis in patients with tooth loss after surgery for different serum PGRN and PTX3 levels was compared.The receiver operating characteristic(ROC)curve was used to evaluate the predictive value of serum PGRN and PTX3 levels for peri-implant mucositis in patients with tooth loss after surgery.Results The patients in the mucositis group had a higher proportion of diabetes and smoking,as well as a higher serum PTX3 level compared to the non-mucositis group.The PGRN level was lower than that of the non-mucositis group.The differences were statistically significant(P＜0.05).Smoking,dia-betes,and PTX3 were independent risk factors for postoperative peri-implant mucositis in patients with dentition loss,while PGRN was an independent protective factor(P＜0.05).The relative risk of postoperative peri-implant mucositis in dentition loss patients with PGRN ≥95.58 and PTX3 ≥ 12.64 was 0.404 times and 3.141 times that of patients with PGRN＜95.58 and PTX3＜12.64(P＜0.05).The area under curve(AUC)of the combined prediction of PGRN and PTX3 for postoperative peri-implant mucositis in patients with dentition loss was 0.945,which was superior to the single prediction of PGRN and PTX3.Conclusion In patients with Edentulism who developed peri-implant mucositis after surgery,the serum levels of PGRN decreased while the levels of PTX3 increased.The combination of these two indicators has a higher value in predicting the occurrence of peri-implant mucositis in patients with Edentulism after surgery.