非小细胞肺癌组织预后的影响因素分析OA

Objective To explore the factors influencing the prognosis of patients with non-small cell lung cancer(NSCLC),and to provide a basis for postoperative survival assessment.Methods A total of 106 NSCLC patients who underwent surgery at Fuxin General Hospital of Liaoning Health Industry Group from October 2020 to May 2022 were selected as the research subjects.The total survival rate was statistically analyzed over a 3-year follow-up period.Part of NSCLC tissues from the operation were taken and the protein expressions of B-cell translocation gene-2(BTG-2)and thyroid hormone receptor interacting protein-6(TRIP-6)were detected by immunohistochemistry.The survival curves of patients with positive and negative BTG-2 and TRIP-6 protein expressions were plotted using the Kaplan-Meier method.The patients were divided into the death group(n=47)and the survival group(n=59)based on the prognosis.Univariate and multivariate Cox regression analyses were used to investigate the influencing factors of the prognosis of NSCLC patients.Results The survival rate of 106 NSCLC patients was 55.66%(59/106).Among them,the survival rate of patients with positive BTG-2 protein was higher than that of patients with negative BTG-2 protein,and the survival rate of patients with positive TRIP-6 protein was lower than that of patients with negative TRIP-6 protein,with statistically significant differences(P＜0.05).The proportion of tu-mor size≥3 cm,the proportion of poorly differentiated,the proportion of TNM stage Ⅲ,the proportion of lymph node metas-tasis,and the proportion of positive TRIP-6 protein in the death group were greater than those in the survival group,while the proportion of positive BTG-2 protein in the death group was lower than that in the survival group.The differences were statistically significant(P＜0.05).Poor differentiation(HR=2.055,95%CI:1.101-3.835,P=0.024),TNM stage Ⅲ(HR=1.971,95%CI:1.089-3.568,P=0.025),lymph node metastasis(HR=2.228,95%CI:1.092-4.548,P=0.028),and positive TRIP-6 protein expression(HR=2.242,95%CI:1.213-4.145,P=0.010)were independent risk factors for the death of NSCLC patients,while positive BTG-2 protein expression(HR=0.315,95%CI:0.110-0.899,P=0.031)was an independent protective factor for the death of NSCLC patients.Conclusion In the NSCLC tissue,positive BTG-2 and expression TRIP-6 are associated with poor prognosis,and they may become new markers for evaluating the prognosis of NSCLC patients.