马鹿鞭肽对环磷酰胺致大鼠性功能障碍的改善作用OA

To investigate the ameliorative effects on rats with sexual dysfunction of Cervus elaphus peptide,a sexual dysfunction model was established in SD rats by intraperitoneal injection of cyclophosphamide(CTX).The rats were administered with sildenafil and Cervus elaphus peptide via gavage.Body weight,organ indexes,serum levels of testosterone(T),luteinizing hormone(LH),and nitric oxide(NO)were measured,and pathological changes in kidney and testicular tissues were observed.The results showed that various amino acids of Cervus elaphus peptide were rich with a high content of arginine;peptides with molecular weight below 1 000 Da accounted for 68.92%of the total.Compared with the blank control group,the model group exhibited decrease in body weight,kidney index,testicular index,thymus index,and serum levels of testosterone,luteinizing hormone,and nitric oxide,along with obvious pathological lesions in kidney and testicular tissues.In the low-and high-dose groups of Cervus elaphus peptide,all the above indicators were improved to varying degrees.These findings indicate that Cervus elaphus peptide has high nutritional value,consists mainly of short-chain peptides,and can effectively increase organ indexes and serum levels of testosterone,luteinizing hormone,and nitric oxide,as well as alleviate pathological changes in testicular tissues,thereby improving sexual function.The results provide a reference for the development and application of Cervus elaphus peptide in functional foods or drugs for improving sexual dysfunction.