NLRP3炎性小体在肝缺血/再灌注损伤中作用的研究进展OA
Research progress in the role of NLRP3 inflammasome in hepatic ischemia-reperfusion injury
肝缺血/再灌注损伤(HI/RI)是肝脏外科手术中不可避免的病理生理过程,是导致术后严重并发症发生的重要因素.其机制复杂,涉及氧化应激、细胞内钙过载、炎性反应等多种途径,近年来,NOD 样受体热蛋白结构域相关蛋白 3(NLRP3)炎性小体作为天然免疫反应的重要调控枢纽,在 HI/RI 中发挥核心作用.本文旨在系统综述NLRP3 炎性小体的结构功能、在 HI/RI 中的激活机制及其核心作用,并探讨以 NLRP3 为靶点的多种干预策略的研究现状与挑战,为 HI/RI 的临床防治提供新的理论视角和策略方向.
Hepatic ischemia-reperfusion injury(HI/RI)is an inevitable pathophysiological process in liver surgery and is an important factor leading to severe postoperative complications.Its mechanism is complex,involving multi-ple pathways such as oxidative stress,intracellular calcium overload,and inflammatory response.In recent years,as an important regulatory hub of the innate immune response,the NOD-like receptor thermal protein domain asso-ciated protein 3(NLRP3)inflammasome has played a core role in HI/RI.This article reviews the structure and function of the NLRP3 inflammasome,its activation mechanism in HI/RI to identify the core role of this molecule and to explore the research status and challenges of various intervention strategies targeting NLRP3,providing new theoretical perspectives and orientation for clinical prevention and treatment of HI/RI.
刘翠玲;于树娜
山东第二医科大学 基础医学院 人体解剖学教研室,山东 潍坊 261053||潍坊护理职业学院 医学技术系,山东 潍坊 262500山东第二医科大学 基础医学院 人体解剖学教研室,山东 潍坊 261053
医药卫生
炎性小体肝缺血/再灌注损伤细胞焦亡炎性反应靶向治疗
inflammasomehepatic ischemia-reperfusion injurypyroptosisinflammatory responsetargeted therapy
《基础医学与临床》 2026 (7)
1004-1008,5
山东省医药卫生科技发展计划(202001020642)
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