加味麻杏石甘散对犊牛呼吸道疾病症状评分和炎症指标的影响OA

This study aims to evaluate the clinical efficacy and anti-inflammatory effects of Modified Maxing Shigan Powder(Feiyan Kang)in the treatment of bovine respiratory disease(BRD),and to pro-vide a theoretical basis for the development and promotion of pure Chinese herbal preparations for the pre-vention and treatment of BRD.45 calves naturally infected with BRD were divided into a modified Maxing-shigan powder treatment group(Group F,n=30)and a Maxingshigan powder treatment group(Group M,n=15),with a healthy control group(Group C,n=15)also established.Both treatment groups re-ceived corresponding medications via oral administration(2 g/kg BW)for 7 consecutive days.Clinical symptom scores and therapeutic efficacy were assessed after treatment,and serum inflammatory factors,acute-phase proteins,and tissue injury-related indicators were measured.The results showed that the clini-cal symptom scores of both Group F and Group M significantly reduced after treatment,with group F ex-hibiting a faster onset of action.On day 7,the cure rate in Group F was 80％,and 73.3％in Group M.Ser-um levels of inflammatory factors(TNF-α,IL-1β),acute-phase proteins(SAA,HP),and lactate dehy-drogenase(LDH)activity significantly decreased in both treatment groups.No significant changes were observed in myeloperoxidase(MPO)activity or antioxidant indicators.Compared with the control group,no significant changes in serum biochemical indicators were found in the treatment groups,indicating that the Modified Maxing Shigan Powder has no hepatotoxicity or nephrotoxicity.In summary,Modified Ma-xing Shigan Powder significantly improves the clinical symptoms of BRD by reducing inflammatory fac-tors,acute-phase protein levels,and tissue damage,with favorable safety profile.