疏肝化痰方治疗肝郁夹痰型持续性姿势感知性头晕伴焦虑抑郁状态的临床研究OA
Clinical Study of Shugan Huatan Formula in Treatment of Persistent Postural-Perceptual Dizziness with Anxiety and Depression of Liver Stagnation with Phlegm Retention Syndrome
目的:探究疏肝化痰方治疗肝郁夹痰型持续性姿势感知性头晕(persistent postural-perceptual dizziness,PPPD)并伴随焦虑抑郁状态患者临床疗效及机制.方法:选取2023年12月至2024年12月就诊于石家庄市中医院脑病科门诊诊断为肝郁夹痰型PPPD且伴有焦虑抑郁状态的85例患者,利用随机数字表法分为对照组43例和治疗组42例.对照组予草酸艾司西酞普兰片治疗,治疗组在对照组的基础上予疏肝化痰方中药免煎颗粒治疗,疗程为6周.比较2组患者治疗前后中医证候评分、眩晕障碍量表(DHI)评分、Niigata PPPD问卷(NPQ)评分、抑郁自评量表(SDS)评分、焦虑自评量表(SAS)评分,以及血清白细胞介素-6(IL-6)、脑源性神经营养因子(BDNF)水平,评估临床疗效并比较治疗期间不良反应.结果:和治疗前比较,2组患者治疗后中医证候评分、DHI评分、NPQ评分、SDS评分、SAS评分以及IL-6水平均降低(P<0.05),BDNF水平升高(P<0.05);且治疗组优于对照组(P<0.05).治疗组临床疗效优于对照组(P<0.05).2组患者不良反应发生率比较差异无统计学意义(P>0.05).结论:疏肝化痰方可以改善肝郁夹痰型PPPD伴焦虑抑郁状态患者的临床症状,缓解焦虑抑郁情绪,降低炎症因子水平,具有较高的安全性.
Objective:To explore the clinical efficacy of Shugan Huatan Formula in the treatment of patients with persistent postural-perceptual dizziness(PPPD)complicated with anxiety and depression state of liver stagnation with phlegm retention syndrome,and to investigate its underlying mechanism.Methods:A total of 85 patients diagnosed with PPPD of liver stagnation with phlegm retention syndrome complicated with anxiety and depression state were enrolled from the outpatient department of Encephalopathy Department,Shijiazhuang Hospital of Traditional Chinese Medicine,from December 2023 to December 2024.All patients were randomly divided into the control group(43 cases)and the treatment group(42 cases)using the random number table method.Patients in the control group were treated with Escitalopram Oxalate Tablets,while the treatment group was additionally given Shugan Huatan Formula granules on the basis of the control group,with a treatment course of 6 weeks.Before and after treatment,the TCM syndrome score,Dizziness Handicap Inventory(DHI)score,Niigata PPPD Questionnaire(NPQ)score,Self-rating Depression Scale(SDS)score,Self-rating Anxiety Scale(SAS)score,as well as serum levels of interleukin-6(IL-6)and brain-derived neurotrophic factor(BDNF)were compared between the two groups.The clinical efficacy was evaluated,and adverse reactions during treatment were compared.Results:After treatment,both groups presented significantly decreased TCM syndrome scores,DHI scores,NPQ scores,SDS scores,SAS scores and serum IL-6 levels,while the serum BDNF levels were significantly increased compared with those before treatment(all P<0.05).The treatment group showed superior improvement in the above indicators to the control group(P<0.05).The overall clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Shugan Huatan Formula can improve clinical symptoms,relieve anxiety and depression,and reduce the level of inflammatory factors in PPPD patients with liver stagnation and phlegm retention syndrome,which possesses high clinical safety.
邢永淇;郭君荣;贾昕宇;王彩娟
华北理工大学,河北 唐山 063210华北理工大学,河北 唐山 063210河北北方学院,河北 张家口 075000石家庄市中医院,河北 石家庄 050051
医药卫生
持续性姿势感知性头晕焦虑抑郁状态疏肝化痰方肝郁夹痰脑源性神经营养因子白细胞介素-6
Persistent postural-perceptual dizzinessanxiety and depression stateShugan Huatan Formulaliver stagnation with phlegm retentionbrain-derived neurotrophic factorinterleukin-6
《河北中医药学报》 2026 (3)
15-19,25,6
河北省中医药管理局科研计划项目(2022452)
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