基于"温阳解郁"理论通督针法联合化风丹对卒中后抑郁患者抑郁评分及5-羟色胺、同型半胱氨酸水平的影响OA
Effects of Tongdu acupuncture based on"warming yang and resolving depression"theory and Huafeng Dan on depression scores and levels of 5-hydroxytryptamine and homocysteine in patients with post-stroke depression
目的 观察基于"温阳解郁"理论的通督针法联合化风丹对卒中后抑郁(PSD)患者抑郁评分及 5-羟色胺(5-HT)、同型半胱氨酸(Hcy)水平的影响.方法 回顾性选择 2021 年 5 月至 2023 年 11 月滨州医学院附属中医医院针灸推拿科 72 例 PSD 患者作为研究对象,根据治疗方案不同分为治疗组(n=36)和对照组(n=36).2 组均予西酞普兰治疗,对照组加常规针刺治疗,治疗组加"温阳解郁"理论的通督针法联合化风丹治疗.比较2 组治疗前后汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、改良 Barthel 指数(mBI)、美国国立卫生研究院卒中量表(NIHSS)评分及 Hcy、5-HT水平,统计 2 组不良反应.结果 治疗后,2 组 HAMA、HAMD、NIHSS 评分均明显低于治疗前(P<0.05),且治疗组均低于对照组(P<0.05).治疗后,2 组 mBI 评分均升高(P<0.05),且治疗组高于对照组(P<0.05).治疗后,2 组血清5-HT水平均较治疗前升高(P<0.05),且治疗组高于对照组(P<0.05);治疗后,2 组血清 Hcy 水平均较治疗前降低(P<0.05),且治疗组血清 Hcy 水平低于对照组(P<0.05).治疗组和对照组不良反应发生率分别为 13.89%(5/36)、5.56%(2/36),2 组不良反应发生率比较差异无统计学意义(P>0.05).结论 基于"温阳解郁"理论的通督针法联合化风丹治疗 PSD 效果显著,有助于减轻抑郁症状,调节 5-HT、Hcy 水平,且具有较高安全性.
Objective To observe the effects of Tongdu acupuncture based on the theory of"warming yang and resolving depression,"combined with Huafeng Dan on depression scores and serum levels of 5-hydroxytryptamine(5-HT)and homocysteine(Hcy)in patients with post-stroke depression(PSD).Methods A retrospective analysis was conducted on 72 patients with PSD treated in the Department of Acupuncture and Tuina,Affiliated Hospital of Traditional Chinese Medicine of Binzhou Medical University,from May 2021 to November 2023.According to different treatment regimens,the patients were divided into a treatment group(n=36)and a control group(n=36).Both groups received citalopram.The control group additionally received conventional acupuncture,while the treatment group received Tongdu acupuncture based on the theory of"warming yang and resolving depression"combined with Huafeng Dan.The Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD),Modified Barthel Index(MBI),National Institutes of Health Stroke Scale(NIHSS),and serum levels of Hcy and 5-HT before and after treatment were compared between the two groups.Adverse reactions were also recorded.Results After treatment,HAMA,HAMD,and NIHSS scores were significantly lower in both groups than before treatment(P<0.05),and all were lower in the treatment group than in the control group(P<0.05).After treatment,MBI scores increased in both groups,and the treatment group had a higher MBI score than the control group(P<0.05).After treatment,serum 5-HT levels increased in both groups compared with pre-treatment levels(P<0.05),and the treatment group had higher 5-HT levels than the control group(P<0.05).Serum Hcy levels decreased in both groups after treatment compared with before treatment(P<0.05),and the treatment group had lower serum Hcy levels than the control group(P<0.05).The incidence of adverse reactions was 13.89%(5/36)in the treatment group and 5.56%(2/36)in the control group;the difference between the two groups was not statistically significant(P>0.05).Conclusion Tongdu acupuncture based on the theory of"warming yang and resolving depression"combined with Huafeng Dan has significant efficacy in the treatment of PSD,helps alleviate depressive symptoms,regulates 5-HT and Hcy levels,and demonstrates a high level of safety.
王金玉;李静;刘士萍
滨州医学院附属中医医院针灸推拿科,山东 滨州 256600滨州医学院附属中医医院针灸推拿科,山东 滨州 256600滨州医学院附属中医医院针灸推拿科,山东 滨州 256600
医药卫生
卒中后抑郁温阳解郁针刺疗法通督化风丹
Post stroke depressionWarming yang and relieving depressionAcupunctureTongduHuafeng Dan
《河北中医》 2026 (6)
983-986,4
山东省中医药科技项目(编号:2021Q017)
评论