血浆细胞周期依赖性激酶9水平与急性大动脉粥样硬化型脑梗死病情进展及预后的相关性OA
Correlation between plasma cyclin-dependent kinase 9 level and disease progression and prognosis in patients with acute large artery atherosclerotic cerebral infarction
目的 探讨血浆细胞周期依赖性激酶9(CDK9)水平与大动脉粥样硬化(LAA)型脑梗死病情进展及预后的相关性,评估其作为疾病风险分层及预后评估生物标志物的临床价值.方法 选取2020年1月—2024年12月期间于本院就诊的400例急性LAA型脑梗死患者作为观察组,并同期纳入100名健康体检者作为对照组.发病90 d后,采用改良Rankin量表(mRS)对所有患者进行预后评估.根据评估结果,将观察组进一步划分为预后不良组(152例)与预后良好组(248例).检测患者血浆CDK9水平并收集临床资料.分析CDK9水平与美国国立卫生研究院卒中量表(NIHSS)评分、梗死灶体积的相关性;分析预后不良的影响因素.结果 观察组CDK9水平高于对照组[(185.6±42.3)pg/mL vs(62.4±18.5)pg/mL,P＜0.001],且与梗死体积(r=0.586)、NIHSS评分(r=0.628)、高敏C反应蛋白(r=0.452)及白介素6(r=0.418)呈正相关(均P＜0.001).多因素Logistic回归分析显示,CDK9升高是90天预后不良的独立危险因素.受试者工作特征曲线(ROC)曲线分析显示,CDK9预测预后不良的曲线下面积(AUC)为0.854(最佳截断值为198.6 pg/mL,灵敏度为78.3%,特异度为82.5%),联合NIHSS评分及梗死体积后AUC提升至0.912(P＜0.001).结论 血浆CDK9水平可作为急性LAA型脑梗死病情进展及预后的独立预测标志物,联合传统指标可提高预后评估效能.
Objective To investigate the correlation between plasma cyclin-dependent kinase 9(CDK9)level and disease progression and prognosis in patients with acute large artery atherosclerosis(LAA)cerebral infarction,and to evaluate its clinical value as a biomarker for disease risk stratification and prognostic assessment.Methods This study enrolled 400 patients with acute LAA-type cerebral infarction who visited our hospital between January 2020 and December 2024 as the observation group,along with 100 healthy individuals as the control group during the same period.After 90 days of symptom onset,all patients were assessed using the modified Rankin Scale(mRS)for prognostic evaluation.Based on the assessment results,the observation group was further divided into two subgroups:the poor prognosis group(152 cases)and the good prognosis group(248 cases).Plasma CDK9 levels were measured,and clinical data were collected.The correlation between CDK9 level and National Institutes of Health Stroke Scale(NIHSS)score and infarct volume,and the factors affecting poor prognosis were analyzed.Results Plasma CDK9 levels in the observation group were higher than those in the control group([185.6±42.3]pg/mL vs[62.4±18.5]pg/mL,P＜0.001),and were positively correlated with infarct volume(r=0.586),NIHSS score(r=0.628),high-sensitivity C-reactive protein(r=0.452),and interleukin-6(r=0.418)(all P＜0.001).Multivariate Logistic regression analysis showed that elevated CDK9 level was an independent risk factor for poor prognosis at 90 d.Receiver Operating Characteristic(ROC)curve analysis revealed that the area under the curve(AUC)of CDK9 for predicting poor prognosis was 0.854(optimal cut-off value:198.6 pg/mL,sensitivity:78.3%,specificity:82.5%),and the AUC increased to 0.912 when combined with NIHSS score and infarct volume(P＜0.001).Conclusions Plasma CDK9 level may serve as an independent predictive biomarker for disease progression and prognosis in acute LAA cerebral infarction,and combining it with traditional indicators can improve the efficacy of prognostic assessment.
李海霞;梁金花;苏楠;赵宛玉;张凯
濮阳市人民医院神经内科(河南 濮阳 457000)濮阳市人民医院神经内科(河南 濮阳 457000)濮阳市人民医院神经内科(河南 濮阳 457000)濮阳市人民医院神经内科(河南 濮阳 457000)濮阳市人民医院神经内科(河南 濮阳 457000)
细胞周期依赖性激酶9大动脉粥样硬化型脑梗死预后生物标志物炎症反应
cyclin-dependent kinase 9large artery atherosclerotic cerebral infarctionprognosisbiomarkerinflammatory response
《广州医药》 2026 (5)
625-632,8
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