PPARα activation alleviates lithocholic acid-induced liver injury by inhibiting pyroptosisOA
PPARα activation alleviates lithocholic acid-induced liver injury by inhibiting pyroptosis
Hang-Fei Liang;Hui-Chang Bi;Chuo-Ying Mai;Xuan Li;Jia-Ning Tian;Hai-Guo Su;Min Huang;Jian-Hong Fang;Hai-Tao Wang;Xiao Yang
NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening&Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou,Guangdong,China||Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou,Guangdong,ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening&Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou,Guangdong,China||Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou,Guangdong,China||The State Key Laboratory of Chemical Oncogenomics,School of Chemical Biology and Biotechnology,Shenzhen Graduate School of Peking University,Shenzhen,Guangdong,ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening&Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou,Guangdong,ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening&Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou,Guangdong,ChinaGuangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou,Guangdong,ChinaGuangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou,Guangdong,ChinaGuangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou,Guangdong,ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening&Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou,Guangdong,ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening&Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou,Guangdong,ChinaNMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening&Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou,Guangdong,China||The State Key Laboratory of Chemical Oncogenomics,School of Chemical Biology and Biotechnology,Shenzhen Graduate School of Peking University,Shenzhen,Guangdong,China
Cholestatic liver injury(CLI)Peroxisome proliferator-activated receptor alpha(PPARα)PyroptosisNOD-like receptor protein 3(NLRP3)Apoptosis protease-activating factor-1(APAF-1)
Cholestatic liver injury(CLI)Peroxisome proliferator-activated receptor alpha(PPARα)PyroptosisNOD-like receptor protein 3(NLRP3)Apoptosis protease-activating factor-1(APAF-1)
《肝脏研究（英文）》 2026 (2)
177-188,12
This work was supported by the National Key R&D Program of China(2022YFA1106700 and 2022YFA1104900),the National Natural Science Foundation of China(82274001,U23A20535,and 82204226),the Shenzhen Science and Technology Program(KQTD20190929174023858),the Guangdong Basic and Applied Basic Research Foundation(2024A1515011086),and the Natural Science Foundation of Sichuan Province(2024NSFSC0638).
评论