宿主与肠道微生物互作调控猪骨骼肌生长发育研究进展OA

Skeletal muscle is the largest metabolic organ in the body,and its growth and development directly affect the meat yield and meat quality of pigs;thus,its regulatory mechanism has long been a key research focus in the field of animal husbandry.In recent years,as an invisible organ of the host,the intestinal microbiota plays a critical regulatory role in the growth,development,and functional maintenance of skeletal muscle through bidirectional interactions with the host.This review summarizes the molecular mechanisms by which the intestinal flora mediates host regulation of skeletal muscle development,including differences in microbial communities among pig breeds and the regulatory pathways of myogenic genes;it outlines the effects of intestinal microorganisms on skeletal muscle mass,muscle fiber morphology and protein metabolism;and it analyzes the bidirectional interaction network between the host and microbiota as well as its regulatory applications in pig production.This review aims to further clarify the molecular mechanism underlying the regulation of porcine skeletal muscle development via host-intestinal microbiota interactions,and to provide theoretical references and research insights for developing green and efficient strategies to improve pork quality.