惊恐障碍脑电图研究进展:现状、挑战与展望OA

Panic disorder is a common acute anxiety disorder characterized by sudden panic attacks that severely impact patients' daily lives.In recent years,electroencephalogram(EEG)and event-related potentials(ERP)techniques have played a crucial role in elucidating the neural mechanisms underlying this condition.Resting-state EEG studies have demonstrated abnormalities such as frontal alpha asymmetry,altered EEG microstates and impaired functional brain network connectivity in patients with panic disorder.Meanwhile,ERP investigations using paradigms such as Oddball,Go/NoGo,Stroop and Flanker have revealed deficits in cognitive functions including attentional allocation,inhibitory control and error monitoring.However,existing research is limited by methodological heterogeneity,small sample sizes and a lack of longitudinal designs.Future studies should focus on establishing standardized protocols,promoting multi-center collaborations with larger samples and incorporating advanced techniques such as high-density EEG,source localization,machine learning and longitudinal studies.This integrated approach is critical to identifying reliable neuroelectrophysiological biomarkers for the early diagnosis and personalized treatment of panic disorder.