脓毒症后综合征的病理生理学机制研究进展OA
Research progress on the pathophysiological mechanisms of post-sepsis syndrome
脓毒症后综合征是脓毒症后,难以用其他疾病解释,长期存在躯体、认知及精神心理问题的临床综合征,严重影响患者远期生存质量.其病理生理演变并非急性期器官损伤的简单延续,而是经历急性代谢-免疫重编程、持续性炎症-免疫抑制-分解代谢综合征及慢性器官功能重塑的连续过程.本文从上述角度出发进行综述,旨在为脓毒症后综合征分层干预策略提供理论依据.
Post-sepsis syndrome(PSS)is a clinical syndrome that occurs after sepsis and is difficult to explain with other diseases.It is characterized by long-term physical,cognitive,and psychosocial problems that significantly affect the long-term quality of life of sepsis survivors.The pathophysiological evolution does not merely extend from acute organ damage but involves a continuous process of acute metabolic-immune reprogramming,persistent inflammation-immunosuppression-catabolism syndrome(PICS),leading to chronic organ remodeling.This review aims to provide a theoretical basis for stratified intervention strategies for post-sepsis syndrome from the above perspectives.
姚奕;赵光举
温州医科大学附属第一医院急诊医学科,浙江 温州 325000温州医科大学附属第一医院急诊医学科,浙江 温州 325000
脓毒症脓毒症后综合征代谢重编程持续性炎症-免疫抑制-分解代谢综合征靶器官损伤
sepsispost-sepsis syndromemetabolic reprogrammingpersistent inflammation-immunosuppression-catabolism syndrometarget organ injury
《感染、炎症、修复》 2026 (3)
267-271,5
国家自然科学基金(82272202),温州市高水平创新团队项目(2024R3002).
评论