可生物降解聚合物支架的进展:综述OA

Cardiovascular diseases(CVDs)are the leading cause of global mortality,and impose a significant burden on healthcare systems worldwide.Traditional treatments,such as metallic stents,often lead to long-term complications,including restenosis,thrombosis,and chronic inflammation,due to permanent implantation.In response,biodegradable polymeric stents(BPSs)have emerged as a groundbreaking solution,offering temporary mechanical support to diseased vessels while degrading harmlessly over time,thereby promoting natural vascular healing and regeneration.This review synthesizes recent advancements in the development of BPSs,focusing on innovative biodegradable polymers(e.g.,poly(lactic acid)(PLA),poly(lactic-co-glycolic acid)(PLGA),and polycaprolactone(PCL)),and advanced manufacturing methods(e.g.,three-dimensional printing and laser cutting).While preclinical and clinical studies demonstrate promising outcomes,challenges persist in balancing mechanical durability with controlled degradation rates,managing inflammatory responses to acidic byproducts,and ensuring long-term safety.Future directions emphasize smart materials,hybrid manufacturing strategies,and personalized designs enabled by artificial intelligence.By addressing these challenges,BPSs hold transformative potential to redefine cardiovascular interventions,ultimately improving patient outcomes and reducing the global burden of CVDs.