纳米纤维/两性离子水凝胶复合材料用于抗异物反应OA
Nanofiber/Zwitterionic Hydrogel Composite for Anti-Foreign Body Reaction
在本研究中,我们制备了一种纳米纤维/两性离子水凝胶复合材料,用于体内抗异物反应.该复合材料利用聚多巴胺的黏合作用,将三甲胺 N-氧化物两性离子水凝胶与立构复合聚乳酸纳米纤维膜结合在一起.所得复合材料具有聚乳酸良好的力学性能,拉伸强度为 13 MPa 左右,断裂伸长率超过 20%.同时,由于三甲胺 N-氧化物两性离子水凝胶的作用,该复合材料表现出优异的抗生物污染性能.复合材料植入在小鼠体内30 天后,表面仍未形成致密的胶原层,其厚度维持在30 μm 以内.
In this study,we developed a nanofiber/zwitterionic hydrogel composite aimed at overcoming the in vivo foreign body reaction.This composite leverages the adhesive properties of polydopamine(PDA)to integrate trimethylamine N-oxide(TMAO)zwitterionic hydrogel with a three-dimensional poly(lactic acid)(PLA)nanofiber membrane.The resulting material exhibits the robust mechanical properties characteristic of PLA,featuring a tensile strength of approximately 13 MPa and an elongation at break exceeding 20%.Furthermore,owing to the TMAO zwitterionic hydrogel,the composite demonstrates exceptional resistance to biological contamination.After 30 d in a murine model,the composite does not develop a dense collagen layer on its surface,maintaining a thickness of less than 30 μm.
党向宇;高玉洁;陈支泽
东华大学 绿色低碳纺织印染技术教育部重点实验室,化学与化工学院,上海 201620东华大学 绿色低碳纺织印染技术教育部重点实验室,化学与化工学院,上海 201620东华大学 绿色低碳纺织印染技术教育部重点实验室,化学与化工学院,上海 201620
医药卫生
纳米纤维水凝胶抗异物反应两性离子
nanofiberhydrogelanti-foreign body reactionzwitterion
《东华大学学报（英文版）》 2026 (3)
32-43,12
Fundamental Research Funds for the Central Universities,China(No.2232025A-09)
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