从共通病机论治慢性肾脏病OA

Based on the theory of treatment based on pathomechanism differentiation,this article proposes a diagnostic and therapeutic strategy for chronic kidney disease(CKD)from the perspective of common pathogenesis,in light of the pathological characteristics of its occurrence,progression,and outcome.It systematically demonstrates that renal collateral concretions and masses represent a common pathogenic mechanism throughout the evolution of different primary CKD entities.Its formation and progression follow a vicious cycle characterized by collateral damage leading to concretions and masses formation,and accumulated concretions and masses further damaging the collaterals,which continuously aggravates injury to the kidney collaterals during chronic disease,thereby driving persistent renal function decline and disease progression.On this basis,this article identifies dissolving concretions and dispersing masses as the core therapeutic principle for CKD,and further constructs a diagnostic and therapeutic approach integrating stage-based treatment with disease-specific treatment.Along the longitudinal course of disease progression,CKD is divided into early,middle,and late stages according to the dynamic pathomechanism evolution,which are treated respectively by unblocking collaterals and resolving concretions,activating blood and resolving concretions,and reinforcing healthy qi and resolving concretions.According to the pathological features of different primary kidney diseases,specific therapeutic method are proposed across the horizontal dimension of disease categories,including clearing heat and replenishing qi to dissolve concretions,activating blood and unblocking collaterals to dissolve concretions,and dispelling wind and eliminating dampness to dissolve concretions.This framework contributes to a holistic understanding of the complex evolution of CKD pathomechanisms and provides a systematic traditional Chinese medicine theoretical basis and practical clinical pathway for delaying disease progression and improving patient prognosis.