动脉型肺动脉高压与冠状动脉疾病和肾脏疾病的分子机制关联OA

Pulmonary arterial hypertension(PAH)is a severe pulmonary circulatory disorder characterized by progressive occlusion and remodeling of small pulmonary vessels,ultimately leading to right heart failure and even death.Recent studies suggest that PAH is not confined to the lungs but is closely associated with systemic multi-organ pathologies.However,the precise mechanisms underlying these associations remain incompletely elucidated.This review reveals that PAH may share certain aberrant molecular expression mechanisms with coronary artery disease(CAD)and kidney disease(KD).The dysregulated expression of BRD4,NF-κB,HMGB1,and NFAT contributes to both PAH and CAD,while dysfunctions of the JAG1,LTB4,and NRF2 are implicated in both PAH and KD.These overlapping molecular mechanisms suggest an intrinsic link between PAH,CAD,and KD in their initiation and progression and may thus provide new insights into the pathogenesis of multiple diseases and the development of targeted therapeutic strategies for PAH.