便秘型肠易激综合征因-症分析及腹针联合穴位透药治疗对患者Th1/Th2免疫平衡的影响OA
Etiology-symptom analysis of constipation-type irritable bowel syndrome and impact of abdominal acupuncture combined with acupoint penetration therapy on Th1/Th2 immune balance of patients
目的:对便秘型肠易激综合征(IBS-C)进行因-症分析,并探讨腹针联合穴位透药治疗对患者Th1/Th2免疫平衡的影响.方法:纳入青岛市胶州中心医院2021年9月至2023年9月收治的128例IBS-C患者,根据患者意愿分为对照组(n=63,腹针治疗)、观察组(n=65,腹针联合穴位透药治疗),采用倾向性评分匹配法按1∶1进行匹配,最终每组各60例.观察两组临床疗效、中医证候疗效评价、生活质量评分和血清免疫指标水平变化.结果:观察组临床总有效率显著高于对照组(P<0.05).治疗2周、4周后,两组患者中医证候总积分和单项积分与治疗前相比均降低(P<0.05);治疗2周、4周后,观察组中医证候总积分和单项积分较对照组显著降低(P<0.05).观察组治疗2周、4周后焦虑不安、躯体意念、健康忧虑和挑食评分显著高于对照组(P<0.05).观察组治疗2周、4周后外周血Th1细胞水平和Th1/Th2显著低于对照组,Th2细胞水平显著高于对照组.免疫指标主效应和单独效应检验结果显示,观察组治疗2～4周IL-10水平均显著高于对照组,IFN-γ和IL-2水平显著低于对照组(P<0.05).结论:腹针联合穴位透药治疗IBS-C患者可提高临床疗效、中医证候评价和生活质量评分,改善免疫指标水平,使Th1/Th2达到平衡状态.
Objective:To conduct etiology-symptom analysis of constipation-type irritable bowel syndrome(IBS-C)and investigate effects of abdominal acupuncture combined with acupoint penetration therapy on immune balance of Th1/Th2 in patients.Methods:A total of 128 IBS-C patients admitted to Qingdao Jiaozhou Central Hospital from September 2021 to September 2023 were included in this study.Based on patients'preferences,cohort was stratified into two groups:Control arm(n=63,abdominal acupunc-ture treatment)and observational arm(n=65,abdominal acupuncture combined with acupoint penetration therapy).To ensure compa-rability,1∶1 propensity score matching approach was employed,ultimately yielding a balanced sample of 60 patients in each group.Clinical efficacy,traditional Chinese medicine syndrome efficacy evaluation,quality of life score,and changes in serum immune indi-cators were observed in both groups.Results:Clinical treatment efficacy in observational group notably surpassed of control group(P<0.05).Significant reductions in total and individual scores of traditional Chinese medicine syndrome scores post-treatment at 2 and 4 weeks compared to baseline(P<0.05).Observational group demonstrated more pronounced declines in scores at 2 and 4 weeks(P<0.05),including anxiety,physical obsession,health anxiety,and picky eating compared to control group at 2 and 4 weeks(P<0.05).Th1 cell level and Th1/Th2 in peripheral blood of observation group were significantly lower than control group 2 and 4 weeks after treatment,while Th2 cell level was significantly higher than control group.Analysis of immune markers showed that observational group had significantly elevated IL-10 levels and reduced IFN-γ and IL-2 levels after 2～4 weeks of treatment,as confirmed by both main and independent effect tests(P<0.05).Conclusion:Abdominal acupuncture combined with acupoint penetration therapy for patients with IBS-C can improve clinical efficacy,traditional Chinese medicine syndrome evaluation,and quality of life scores,and achieve balanced of Th1/Th2 by improving levels of immune indicators.
宋希暖;王晓娟;白天玉;吴美英
青岛市胶州中心医院消化内科,胶州 266300青岛市胶州中心医院消化内科,胶州 266300青岛市胶州中心医院影像中心,胶州 266300青岛市胶州中心医院消化内科,胶州 266300
医药卫生
便秘型肠易激综合征因-症分析腹针联合穴位透药Th1/Th2免疫平衡
Constipation-type irritable bowel syndromeEtiology-symptom analysisAbdominal acupuncture combined with acupoint penetrationTh1/Th2 immune balance
《中国免疫学杂志》 2026 (6)
1409-1418,10
青岛市2023年度医药卫生科研指导项目(2023-WJZD144)2022-2024年青岛市市级临床重点专科胃肠道肿瘤综合治疗专科建设项目.
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