小肠细菌过度生长伴肠易激综合征的病理机制与中医药治疗研究进展OA

Irritable bowel syndrome(IBS)is a common functional bowel disorder clinically,which is characterized by a complex etiology involving the interplay of multiple factors.Small intestinal bacterial overgrowth(SIBO)plays a critical role in the pathogenesis of IBS.The significant overlap in clinical symptoms of IBS and SIBO suggests that SIBO may contribute to the onset and progression of IBS via multiple pathways,including impaired intestinal motility,damage to the intestinal mucosal barrier,activation of immune-inflammatory responses,and disruption of the Gut-Brain Axis.By systematically reviewing the association between IBS and SIBO,their underlying mechanisms,and the therapeutic advances in traditional Chinese medicine(TCM),it is found that TCM,capitalizing on its multi-target and holistic regulatory approach,exhibits unique potential in inhibiting bacterial overgrowth,alleviating inflammation,and modulating gastrointestinal motility,and is associated with a low recurrence rate.