子宫内膜癌的病理学诊断OA

Endometrial carcinoma(EC)is a group of tumors with heterogeneous pathogenesis and pathological manifestations,and different histopathological subtypes of endometrial cancer present different clinical manifestations and biological behaviors.The previous clinical treatment mainly relied on histopathological changes in the development of treatment plans.However,the classical pathological diagnosis based solely on histopathological classification and grading showed low reproducibility and clinical prognostic correlation.In 2013,the molecular classification of EC introduced by The Cancer Genome Atlas(TCGA)has a clear value forjudging the prognosis of EC.Therefore,in recent years,the pathological diagnosis of EC has progressed from a simple basis on histopathological morphology to a comprehensive diagnosis combining pathological morphology and molecular detection results.This article introduces the advances in the pathological diagnosis of EC based on the fifth edition of the WHO classification of endometrial cancer and through combination with the molecular classification of EC.