抑郁症患者治疗前后情绪识别缺陷与认知功能变化的相互关系OACHSSCD

Objective:To investigate the changes in emotion recognition ability and cognitive function of pa-tients with depression before and after treatment,and to explore the correlation between the two.Methods:Eighty patients meeting DSM-5 criteria for major depressive disorder received 8-week selective serotonin reuptake inhibitor antidepressants treatment.The ability of emotion recognition and cognitive function were evaluated before and after treatment using facial expression recognition tests and cognitive function tests,respectively.Results:After antide-pressant treatment,the accuracy in recognizing expressions of surprise,disgust and anger was significantly better than the baseline(P＜0.05).Except for social cognition,the scores of cognitive function were significantly im-proved after treatment(P＜0.05).The accuracy of surprise expressions were positively correlated with the scores of verbal learning,working memory,reasoning and problem solving,visual learning(r=0.44,0.43,0.42,0.46,Ps＜0.001).The accuracy of aversive expressions were positively correlated with the scores of verbal learning and memory,working memory,visual learning(r=0.60,0.50,0.45,Ps＜0.001).The accuracy of angry expressions were positively correlated with the scores of verbal learning,working memory,and attention/vigilance(r=0.44,0.53,0.46,Ps＜0.001).Conclusion:Antidepressant treatment improves the negative emotion recognition ability and cognitive function of patients with depression.The improvement of patients'negative emotion recognition abili-ty may be closely related to the recovery of cognitive functions such as speech learning,memory,reasoning ability and attention.