当归有效成分治疗溃疡性结肠炎的研究进展OA

Ulcerative colitis(UC)is a complex chronic inflammatory disease.It is characterized by a prolonged and persistent clinical course,accompanied by a rising tendency in the risk of colorectal cancer.The incidence of UC continues to rise,with a complex etiology and a lack of effective therapeutic agents.TCM has unique advantages in the prevention and treatment of UC,due to its multi-target regulation properties,multi-pathway action,mild side effects,and diverse pharmacological activities.Angelicae Sinensis Radix(AS)contains various active components,including angelica polysaccharides,volatile oils,and organic acids.These components can alleviate UC by a multi-target regulation mechanism,including the inhibition of NF-κB,NLRP3 inflammasome activation,the reduction of the expression of inflammatory factors such as TNF-α and IL-1β,the enhancement of antioxidant enzyme activity,and the up-regulation of tight junction proteins such as ZO-1 and Occludin.Such multi-pathway synergistic effects fully highlight the preventive and therapeutic advantages of TCM,demonstrating the potential application value of AS in the treatment of intestinal diseases.This review systematically elucidated the multidimensional anti-UC mechanisms of the core active ingredients of AS and discussed the translational value of colon-targeted delivery systems,providing effective evidence for clinical precision medication.