p53及其异构体在不同胁迫下的功能OA

p53,a critical tumor suppressor,is mutated in over 50%of human cancers.As a transcription factor,it is activated by diverse stresses.Upon activation,it inhibits cell cycle,induces cellular senescence,or triggers apoptosis to prevent tumorigenesis.p53 gene encodes 12 isoforms through distinct promoters or alternative splicing.It also has two family members,p63 and p73.These proteins exhibit diverse functions.Different isoforms and family members respond to specific stress signals and regulate cell fate by cooperating with,antagonizing,or acting independently of full-length p53 to maintain cellular homeostasis.This review will focus on the regulatory network functions of p53,its isoforms and family members under stress conditions including DNA damage,metabolic dysregulation,heat shock,and tissue injury,providing references for future research.